Subcellular Membrane-less Organization via Macromolecular Phase Separation
Biolmolecular Condensates | Intrinsically Disordered Proteins | Prions | Amyloids | Single-Molecule Biophysics | Molecular and Cell Biology | Chemical & Synthetic Biology | Time-Resolved Spectroscopy | Super-Resolution Imaging
We currently have no openings for PhD positions or internships. Due to the large number of emails/inquiries, I'm unable to reply to all emails regarding internship and PhD opportunities. We can consider a postdoc application only if the applicant has prior experience in cell biology or working with C. elegans worms.
- Samrat Mukhopadhyay
Overview
About Samrat Mukhopadhyay's Laboratory -
Summary of our research: The overarching goal of our lab is to investigate a wide range of fascinating aspects of intrinsically disordered proteins/regions (IDPs/IDRs) that undergo macromolecular phase separation with or without nucleic acids and other biomolecules into biological condensates, also known as membrane-less organelles. We utilize a diverse array of tools and concepts from chemical physics and physical chemistry to chemical biology to biophysics and molecular and cell biology to study the intriguing behavior of IDPs/IDRs that allow them to undergo phase transitions involved in a wide range of cellular functions and neurodegenerative diseases such as Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS), and so forth. For more details, see our Research page.
Cover Page in Biophysical Journal special issue on Biological Condensates (Link):
A two-color, 3D Airyscan, super-resolution microscopy image of multicomponent and multiphasic protein-nucleic acid condensates of two neuronal proteins, tau protein (green) and prion protein (red), in the presence of RNA. Image credit: Sandeep K. Rai, Roopali Khanna, and Samrat Mukhopadhyay.
News and Events
The latest community comment on the current practices in the study of biomolecular condensates, co-authored by Samrat along with 33 other global experts of the field, is now out in Nature Communications.
Our latest paper on condensate-mediated chaperoning of tau is out in Science Advances.
Samrat shares some unheard stories from his intellectual journey in a candid conversation with SciComm Synapse - a group of doctoral and postdoctoral researchers bringing science to the society through real-life stories. Here's the podcast.
Our paper on energy migration via homoFRET to study modulation in the material property of biomolecular condensates is published in Nature Communications (our 4th paper in Nature Comm).
Our paper on the inhibition of pathological prion variant Y145Stop amyloidogenesis by chaperone-mediated heterotypic phase separation is published in the Journal of Molecular Biology.
Samrat co-edited the "Biological Condensates" special issue for Biophysical Journal. Link
Samrat has been awarded the prestigious JC Bose Fellowship.
Our exciting paper on single-molecule FRET in biomolecular condensates is published in Nature Communications (this is our 3rd paper in Nature Communications).
Research Funding
IISER Mohali
Centre for Protein Science, Design and Engineering (Centre of Excellence at IISER Mohali)
